Megestrol acetate Uses:

• Anorexia or cachexia:

  • Suspension:
    • Cachexia, anorexia, or unexplained substantial weight loss in AIDS patients are treated with it.
  • Limitations of use:
    • It is not intended to prevent weight loss.
    • Treatment of the primary disorder is essential and treatment with megestrol should only be initiated once the primary disorder causing anorexia (such as cancer, infection, malabsorption, endocrine disease, kidney disease, or psychiatric disorder) is corrected.

• Breast cancer:

  • The tablet formulation is indicated for the palliative treatment of advanced breast cancer

• Endometrial cancer:

  • It is indicated for the palliative treatment of advanced endometrial carcinoma.

• Off Label Use of Megestrol acetate in Adults:

  • It is used in the treatment of cancer-related cachexia

Megestrol acetate Dose in Adults:

Note:

• Megace ES suspension is not similar to other formulations mg for mg.

Megestrol acetate Dose in the treatment of Anorexia or cachexia associated with AIDS: Oral:

• Suspension:
  • 625 mg daily initially (of the 125 mg/mL suspension)
  • 800 mg daily (of the 40 mg/mL suspension)
  • It has been discovered that doses between 400 mg and 800 mg per day are efficient.

Megestrol acetate Dose in the treatment of advanced Breast cancer:

• Oral: Tablet:
  • For at least two months, take 160 mg each day in four equally spaced doses (each of 40 mg).

Megestrol acetate Dose in the treatment of advanced Endometrial cancer:

• Oral: Tablet:
  • Split doses of 40 to 320 mg every day for a minimum of two months.

Megestrol acetate Dose in the treatment of Cancer-related cachexia (off-label):

• Although the optimum dose has not been established, weight increase was successful at doses of 160 to 800 mg per day, with higher doses surpassing 160 mg being linked to greater weight gain.