Amphotericin B 50mg injection, also known as AmBisome, is available in Pakistan. Some key details:
- AmBisome 50mg injection costs around Rs. 1,000 in Pakistan.
- Other brands of Amphotericin B 50mg injection range from Rs. 618 to Rs. 20,000.
- Amphotericin B is used to treat serious fungal infections.
- The typical dosage is 0.25-0.3 mg/kg, given intravenously once daily or every other day.
- Treatment may need to continue for weeks or months.
- Amphotericin B should be used cautiously in pregnancy and breastfeeding.
- Close monitoring is required due to potential side effects and toxicity.
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- Treats serious, potentially fatal fungal infections:
- Amphotericin B is used to treat a wide range of systemic fungal infections, including aspergillosis, cryptococcosis, candidiasis, and other serious fungal infections.
- Effective against drug-resistant fungi:
- Amphotericin B has a low incidence of drug resistance, making it an effective treatment option for severe fungal infections.
- Used for life-threatening protozoan infections:
- In addition to fungal infections, amphotericin B is also used to treat serious protozoan infections like visceral leishmaniasis and primary amoebic meningoencephalitis.
- Available in Pakistan at affordable prices:
- Amphotericin B 50mg injection is available in Pakistan, with prices ranging from Rs. 618 to Rs. 20,000 depending on the brand.
- The generic brand Amphotret costs around Rs. 1,000, making it accessible for patients.
- Approved by regulatory authorities:
- Amphotericin B is an FDA-approved antifungal medication and is included on the World Health Organization’s List of Essential Medicines.
- Amphotericin B: The active pharmaceutical ingredient, which is a potent antifungal medication. Each vial contains 50 mg of amphotericin B.
- Sodium Desoxycholate: A solubilizing agent that helps dissolve the insoluble amphotericin B to form a colloidal dispersion for intravenous infusion.
- Sodium Phosphates: A buffering system consisting of dibasic and monobasic sodium phosphates, phosphoric acid, and sodium hydroxide. This helps maintain the pH of the solution.
- Nitrogen: The air in the vial is replaced with nitrogen gas during manufacturing.
The key inactive ingredients are:
- Deoxycholic acid (38.75 mg per 10 mL)
- Dibasic sodium phosphate (18.85 mg per 10 mL)
- Monobasic sodium phosphate monohydrate (1.02 mg per 10 mL)
- Phosphoric acid and sodium hydroxide (used for pH adjustment)
- Dose: 0.25-0.3 mg/kg IV daily or every other day
- Infuse slowly over 2-6 hours
- Max dose: 1.5 mg/kg per day
- Treatment duration: weeks to months
- Refrigerate at 2-8°C
- Protect from light, avoid freezing
- Reconstituted solution stable 24 hours refrigerated
- Diluted infusion stable 24 hours refrigerated, 6 hours at room temp
The key points are:
- Dosing range of 0.25-0.3 mg/kg IV, infused slowly
- Maximum daily dose of 1.5 mg/kg
- Treatment may be long-term, from weeks to months
- Requires refrigeration and protection from light
- Limited stability once reconstituted or diluted
- Overall rating of 3.5/5 stars based on 7 reviews
- Ratings for effectiveness range from 1 to 5 stars, with most users finding it effective
- Ratings for ease of use are mixed, from 1 to 5 stars
- Common side effects include infusion reactions like fever, chills, nausea, and headache
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