What is a Sovela 400mg Tablet?

Sovela 400mg Tablets are a combination antiviral medication used primarily to treat chronic hepatitis C virus (HCV) infections in adults and children aged 3 years and older. The active ingredients in Sovela are sofosbuvir and velpatasvir, which work together to inhibit the replication of the virus.

Can I Buy Sovela 400mg Tablet Online in Pakistan?

Yes, you can buy Sovela 400mg Injection from Jasmeds, which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

What Should You Do If You Take an Overdose of Sovela 400mg Tablet?

If you suspect an overdose of Sovela 400mg Tablets (sofosbuvir and velpatasvir), follow these steps: Seek Immediate Medical Attention : Contact a healthcare professional or go to the nearest emergency room right away. Overdosing on Sovela can lead to serious health complications. Contact Poison Control: You can also call your local poison control center for guidance on what to do next. Do Not Induce Vomiting : Unless instructed by a medical professional, do not attempt to induce vomiting or take any other actions without guidance. Provide Information : Be ready to provide information about the amount of Sovela taken, the time of ingestion, and any other medications or substances consumed. Monitoring: Medical professionals will monitor for potential side effects and complications related to the overdose.

Does Sovela 400mg Tablet Affect Kidney Patients?

Yes, sovela 400mg Tablets (sofosbuvir and velpatasvir) can be used in patients with kidney issues, but there are important considerations: Renal Function Impact: Sofosbuvir is primarily eliminated through the kidneys. In patients with severe renal impairment (eGFR <30 mL/min), drug concentrations may increase, which could raise the risk of side effects and toxicity. Mild to Moderate Impairment: For patients with mild to moderate renal impairment (eGFR ≥30 mL/min), Sovela can generally be used without dose adjustments, as studies have shown that the drug's efficacy and safety profile remains acceptable in these populations.

Can I Take Sovela 400mg Tablets Before Driving?

No, t aking Sovela 400mg Tablets (sofosbuvir and velpatasvir) may affect your ability to drive. The medication can cause side effects such as fatigue, headache, dizziness, and nausea, which could impair your alertness and reaction times.

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Sovela 400mg Tablets (Sofosbuvir)

Name: Sovela 400mg Tablets (Sofosbuvir) - Jasmeds
Price: 6500 PKR
Availability: OutOfStock

Sovela 400mg tablet contains (Sofosbuvir) which is now available in Pakistan at Jasmeds. The price range of the Sovela 400mg injection is Rs 3,000 to Rs 9,000/-.

Product Description

Brand: Sovela
Form: Tablets
Packet Size: 28’s Tablets
Active ingredient: (Sofosbuvir + Velpatasuvir)
Manufacturer: Searle
Treatment: Hepatitis C

Original price was: ₨ 12,000.Current price is: ₨ 6,500.

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Description

How Does Sovela 400mg Tablet Work?

Sovela 400mg Tablets, which contain sofosbuvir and velpatasvir, work by targeting the hepatitis C virus (HCV) to inhibit its replication.

Sofosbuvir: Acts as a nucleotide analog that inhibits the HCV NS5B RNA-dependent RNA polymerase, an enzyme essential for viral replication. It gets incorporated into the viral RNA chain, leading to premature termination of RNA synthesis, effectively stopping the virus from multiplying.

Velpatasvir: Functions as a non-structural protein 5A (NS5A) inhibitor, which disrupts the viral replication process by preventing the formation of the replication complex necessary for HCV to replicate its RNA.

How Should You Take Sovela 400mg Tablet?

To take Sovela 400mg Tablets correctly, follow these guidelines:

Timing: It is important to take the tablet at the same time each day to maintain consistent levels of the medication in your body.

With Food: Take the tablet with food to enhance absorption and reduce potential gastrointestinal side effects.

Swallow Whole: Swallow the tablet whole; do not crush, break, or chew it to avoid a bitter taste.

Subsequent Doses: If the first infusion is well-tolerated, future doses may be given over 30 minutes.

Additional Details

Uses of the Sovela 400mg Tablets

Sovela 400mg Tablets are a combination antiviral medication containing sofosbuvir and velpatasvir. They are primarily used for the treatment of chronic hepatitis C virus (HCV) infections in adults and pediatric patients aged 3 years and older.

Key Uses:

Chronic Hepatitis C Treatment: Sovela is indicated for treating various genotypes of chronic hepatitis C, either as a standalone therapy or in combination with other antiviral medications.

Combination Therapy: It is often used in conjunction with other antiviral agents to enhance effectiveness, particularly in patients with specific HCV genotypes.

Recommended Dosage of Sovela 400mg Tablet?

The recommended dosage of Sovela 400mg Tablets, which contain sofosbuvir and velpatasvir, is as follows:

Adults: Take one 400 mg tablet orally once daily, with or without food.

Pediatric Patients (aged 3 years and older): The dosage is weight-based:

≥ 35 kg: One 400 mg tablet once daily.

17 to < 35 kg: One 200 mg tablet once daily.

< 17 kg: Not recommended for tablet use; alternative formulations should be considered.

Following Doses: If the first infusion is well-tolerated, subsequent doses may be given over 30 minutes.

Warnings and Precautions of Sovela 400mg Tablets

Sovela 400mg Tablets (sofosbuvir and velpatasvir) come with several warnings and precautions that should be considered before use:

Warnings:

Hepatitis B Reactivation: Patients with a history of hepatitis B virus (HBV) infection may experience reactivation of HBV during treatment. Testing for HBV should be conducted prior to starting Sovela, and patients should be monitored for signs of HBV reactivation throughout treatment and post-treatment follow-up.

Severe Allergic Reactions: Although rare, serious allergic reactions can occur. Symptoms may include rash, itching, swelling (especially of the face or throat), severe dizziness, and difficulty breathing. Seek immediate medical attention if these symptoms arise.

Depression and Suicidal Ideation: There is a risk of severe depression and suicidal thoughts in some patients. It is important to monitor mental health closely during treatment.

Precautions:

Allergies: Inform your healthcare provider about any known allergies to sofosbuvir, velpatasvir, or any other components of the medication.

Drug Interactions: Be cautious with medications that are strong inducers of P-glycoprotein (e.g., carbamazepine, phenytoin), as they can significantly reduce the effectiveness of Sovela.

Geriatric Use: Elderly patients may be more sensitive to the effects of Sovela, requiring careful monitoring.

Pregnancy and Breastfeeding: The safety of Sovela during pregnancy and breastfeeding has not been fully established; weigh potential benefits against risks before use.

Possible Side Effects of Sovela 400mg Tablets

Sovela 400mg Tablets (sofosbuvir and velpatasvir) can cause a range of side effects. Here are the common and serious side effects associated with this medication:

Common Side Effects:

Fatigue: Unusual tiredness or weakness.

Headache: Frequent headaches may occur.

Nausea: Feeling sick to the stomach.

Diarrhea: Loose or watery stools.

Insomnia: Difficulty sleeping.

Decreased Appetite: Reduced desire to eat.

Less Common Side Effects:

Rash: Skin reactions may occur.

Irritability: Increased feelings of agitation or annoyance.

Mood Changes: Feelings of sadness or emptiness.

Joint Pain: Discomfort in joints.

Serious Side Effects:

Severe Allergic Reactions: Symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing, and hives.

Reactivation of Hepatitis B: In patients with a history of HBV, monitoring is necessary as reactivation can occur.

Mental Health Issues: Severe depression or suicidal thoughts may develop, monitoring for mood changes is essential.

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