Velpaget 400/100mg Tablets (Sofosbuvir)

Velpaget 400/100mg Tablet is a combination of two antiviral medicines: Sofosbuvir and Velpatasvir.

Sofosbuvir is an HCV NS5B polymerase inhibitor.

Velpatasvir is an HCV NS5A inhibitor.

If you suspect an overdose of Velpaget 400/100mg tablets, it is crucial to take immediate action. Here’s what you should do:

Be prepared to give details about the overdose, including:

Symptoms to Watch For:

The amount of Velpaget taken.

The time when it was taken.

Any symptoms that are being experienced.

Do Not Induce Vomiting: Unless instructed by a medical professional, do not try to induce vomiting or take any other medications without guidance.

Yes, Patients with kidney disease, particularly those with end-stage renal disease (ESRD) undergoing dialysis, can use Velpaget 400/100mg tablets, which contain Sofosbuvir and Velpatasvir.

No, you should avoid taking Velpaget 400/100mg Tablet before driving until you know how it affects you. Velpaget is a medication used to treat chronic hepatitis C virus (HCV) infection. 1 It can cause side effects such as fatigue, dizziness, and blurred vision, which could impair your ability to drive safely.

The treatment duration for Velpaget 400/100mg tablets, which contain Sofosbuvir and Velpatasvir, is typically 12 weeks for most patients. 

Recommended Treatment Durations

Therapy-Naive and Therapy-Experienced Patients:

Without Cirrhosis or with Compensated Cirrhosis (Child-Pugh A): 12 weeks of Sofosbuvir-Velpatasvir.

With Decompensated Cirrhosis (Child-Pugh B or C): 12 weeks of Sofosbuvir-Velpatasvir in combination with ribavirin.

Liver Transplant Recipients

Without Cirrhosis or with Compensated Cirrhosis (Child-Pugh A): 12 weeks of Sofosbuvir-Velpatasvir.

Yes, you can buy Velpaget 400/100mg Tablets online in Pakistan from Jasmeds. which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

When taking Velpaget 400/100mg tablets, it is essential to be aware of potential drug interactions that could affect the efficacy and safety of your treatment. Here are the key medicines and substances you should avoid:

Medicines to Avoid

Ritonavir: This medication can cause severe interactions with Velpaget, and should be avoided altogether.

Amiodarone: Co-administration with amiodarone is not recommended due to the risk of serious symptomatic bradycardia (slow heart rate), especially in patients with underlying cardiac conditions.

Potent Inducers of CYP Enzymes:

Rifampin: Commonly used for tuberculosis treatment.

Carbamazepine: An anticonvulsant medication.

St. John’s Wort: An herbal supplement often used for depression

These drugs can significantly reduce the plasma concentrations of Sofosbuvir and Velpatasvir, potentially leading to decreased therapeutic effects.

Drugs that Increase Gastric pH: Medications that reduce stomach acidity (like proton pump inhibitors or antacids) may decrease Velpatasvir serum concentrations. It’s advisable to consult your healthcare provider about the timing of these medications relative to Velpaget.

Other Interacting Medications:

Phenobarbital: Used for seizures.

Certain HIV medications: Including efavirenz, which can decrease the effectiveness of Velpaget.

Warfarin: Blood thinners like warfarin may require close monitoring due to potential interactions affecting INR levels.

The food that you should to avoid while taking velpaget 400/100mg tablet are Grapefruit and grapefruit juice, High-fat meals, Alcohol, Herbal supplements like St. John’s Wort.