Opdivo (Nivolumab) 100mg Injection

Opdivo 100mg Injection contains Nivolumab which is now available in Pakistan at Jasmeds. The price range of the Opdivo 100mg Injection is Rs 70,000/- to Rs 200,000/-.

Product Description

Brand: Opdivo
Form: Injection
Packet Size: 1’s Injection
Active ingredient: Nivolumab
Manufacturer: Bristol Myers Squibb
Treatment: Skin Cancer

Original price was: ₨ 164,000.Current price is: ₨ 90,000.

Description

How Does Opdivo 100mg Injection Work? 

Opdivo works by blocking the interaction between PD-1 and PD-L1, which “unmasks” the cancer cells. This allows your T-cells to recognize and attack the cancer cells, thereby enhancing your immune response against the tumor.

Inhibition of Viral DNA Synthesis:

Ganciclovir selectively targets CMV-infected cells. It inhibits the action of viral DNA polymerase, an enzyme crucial for the replication of the virus’s genetic material. By halting DNA synthesis, the virus cannot multiply or infect additional cells.

Control and Reduction of Viral Load:

By suppressing viral replication, Valcyte helps reduce the viral load in the body, allowing the immune system to recover and combat the infection more effectively.

How Should You Take Opdivo 100mg Injection?

Opdivo 100mg Injection is administered as an intravenous infusion under the supervision of a qualified healthcare professional, typically in a hospital or clinical setting. It is not a medication you can take at home or by yourself. The dosing schedule and duration of treatment are tailored to your specific condition and response to therapy.

Opdivo is delivered through an IV drip over 30–60 minutes.

A nurse or doctor will monitor you during and after the infusion to manage any immediate side effects or reactions.

Your doctor may assess your liver and kidney function, as well as your overall health, before starting treatment.

Let your healthcare provider know if you have a history of autoimmune conditions, organ transplants, or infections.

The treatment can last several months or longer, depending on how well your body responds and tolerates the medication.

Avoid starting other medications, including over-the-counter drugs, supplements, or vaccines, without informing your doctor.

Inform your doctor immediately if you experience any symptoms such as fever, rash, breathing difficulties, or unusual fatigue, as these may indicate side effects.

Additional Details

Uses of the Opdivo 100mg Injection 

Opdivo 100mg Injection, containing nivolumab as its active ingredient, is a prescription medication classified as an immune checkpoint inhibitor. It is primarily used in cancer immunotherapy to help your immune system fight cancer cells more effectively. Opdivo works by blocking the PD-1/PD-L1 pathway, which cancer cells use to evade detection by the immune system.

Non-Small Cell Lung Cancer (NSCLC): Often used in advanced or metastatic stages, either alone or in combination with other therapies.

Melanoma: Effective for treating advanced melanoma after surgical removal or as a part of adjuvant therapy.

Kidney Cancer: Prescribed for advanced renal cell carcinoma, often in combination with other medications like ipilimumab.

Hodgkin Lymphoma: Specifically for cases where other treatments have failed or are unsuitable.

Colorectal Cancer: For patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) tumors.

Head and Neck Cancer: For recurrent or metastatic squamous cell carcinoma.

Liver Cancer (Hepatocellular Carcinoma): As a monotherapy or combined therapy for specific advanced cases.

Warnings and Precautions of Opdivo 100mg Injection

Immune-Mediated Reactions: Severe and potentially fatal immune-mediated adverse reactions can occur in various organs, such as:

Pneumonitis, colitis, hepatitis, endocrinopathies, nephritis, and dermatologic conditions. Close monitoring and prompt management with corticosteroids or other immunosuppressants are necessary if these reactions occur

Infusion Reactions: Opdivo may cause severe infusion-related reactions, including shortness of breath, fever, chills, or rash. Immediate medical attention is required if these symptoms develop during or after infusion

Pregnancy and Breastfeeding: Opdivo may harm an unborn baby. Effective contraception is advised during treatment and for at least 5 months after the last dose. Breastfeeding is not recommended during treatment and for 5 months afterward

Pre-existing Conditions: Patients with autoimmune diseases (e.g., lupus, Crohn’s disease), organ transplants, or prior radiation therapy to the chest should inform their healthcare provider as these conditions may increase the risk of complications

Monitoring: Regular blood tests and clinical evaluations are essential to detect adverse effects early and manage them effectively.

Possible Side Effects of Opdivo 100mg Injection

Opdivo (nivolumab) can lead to various side effects, which can range from common to serious. Here’s a concise overview:

Common Side Effects:

Fatigue: A frequent feeling of tiredness or weakness.

Nausea and Vomiting: Gastrointestinal discomfort often experienced.

Diarrhea or Constipation: Changes in bowel habits.

Skin Reactions: Itching, rash, or other skin irritations.

Muscle and Joint Pain: Discomfort in muscles, bones, or joints.

Headache: Generalized head pain.

Cough and Shortness of Breath: Respiratory symptoms that may develop.

Loss of Appetite: Decreased desire to eat, potentially leading to weight loss.

Serious Side Effects:

Immune-Mediated Reactions: Opdivo can cause the immune system to attack healthy tissues, leading to conditions such as:

Pneumonitis (lung inflammation)

Colitis (intestinal inflammation)

Hepatitis (liver inflammation)

Endocrine disorders (affecting hormone-producing glands)

Severe Allergic Reactions: Symptoms may include difficulty breathing, swelling of the face or throat, and hives.

Infusion Reactions: Can occur during administration, presenting as fever, chills, rash, or difficulty breathing.

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