Sabril 500mg 100’s Tablets (Vigabatrin)

Sabril contains Vigabatrin which is now available in Pakistan at Jasmeds. The price range of the Sabril tablet is Rs 10,000/- to Rs 20,000/-.

Product Description

Brand: Sabril
Form: Tablet
Strength: 500
Size: 100’s Tablets
Active Ingredient: Vigabatrin
Manufacturer: Sanofi

 18,000

Description

Uses of the Sabril 500 mg Tablets 

Sabril 500 mg tablets, which contain the active ingredient vigabatrin, are primarily used for the treatment of specific seizure disorders. Here are the main uses:

Refractory Complex Partial Seizures:

Sabril is indicated as an adjunctive therapy for adults and children aged 2 years and older who experience refractory complex partial seizures. This condition refers to seizures that do not respond adequately to other treatments. Sabril is not intended as a first-line treatment option and should only be used when other medications have failed to provide relief123.

Infantile Spasms:

The medication is also approved for use as a monotherapy in infants aged 1 month to 2 years suffering from infantile spasms, a type of seizure disorder that affects muscle control and development. In this case, Sabril can be used alone to manage the condition effectively.

Additional Details

How Does Sabril 500 mg Tablet Work? 

Sabril (vigabatrin) works by increasing the amount of a neurotransmitter called GABA (gamma-aminobutyric acid) in the brain. GABA is an inhibitory neurotransmitter, which means it helps to calm down the activity of nerve cells. This can help to prevent seizures.

Sabril is used to treat two types of epilepsy:

Refractory complex partial seizures: This is a type of seizure that affects a specific area of the brain and can cause a variety of symptoms, including loss of consciousness, confusion, and jerking movements.

Infantile spasms: This is a type of seizure that occurs in infants and young children. It is characterized by sudden, brief muscle contractions.

How Should You Take a Sabril 500 mg Tablet?

Here are some general guidelines on how to take Sabril 500 mg tablets:

Take Sabril exactly as prescribed by your doctor.

Swallow the tablets whole with a full glass of water. Do not crush or chew the tablets.

You can take Sabril with or without food.

Take Sabril at the same time each day to help you remember to take it.

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Do not stop taking Sabril suddenly without talking to your doctor first.

Warnings and Precautions of Sabril 500mg Tablets

Sabril (vigabatrin 500mg) is effective for treating specific seizure types and infantile spasms, but it carries significant risks. Below are the key warnings and precautions to consider:

1. Risk of Permanent Vision Loss:
Sabril can cause irreversible vision loss due to bilateral concentric visual field defects.
The risk increases with higher doses and longer treatment durations.
Regular eye exams are mandatory:
Before starting treatment
Every 3 months during treatment
After discontinuation
You may not notice symptoms initially, so periodic monitoring is essential.

2. Mental Health Risks:
Sabril may cause or worsen:
Depression
Mood changes
Suicidal thoughts
Report any behavioral or emotional changes to your doctor immediately.

3. Neurological Concerns:
Seizure Worsening: Sabril can sometimes exacerbate absence or myoclonic seizures. Notify your doctor if your seizures worsen.
Drowsiness and Sedation: You may feel excessively tired or sedated, which could affect tasks like driving or operating machinery.

4. Withdrawal Precaution:
Do Not Stop Abruptly: Stopping Sabril suddenly can increase seizure frequency. Always taper the dose under medical supervision.

5. Use in Infants:
For infants with infantile spasms, close monitoring is needed for developmental progress as Sabril may impact growth and development.

6. Kidney Function:
Sabril is eliminated through the kidneys, so if you have kidney disease, your doctor may adjust your dose to avoid drug accumulation.

7. Drug Interactions:
Combining Sabril with CNS depressants (e.g., sedatives, alcohol) can increase drowsiness and sedation. Inform your doctor about all other medications you’re taking.

8. Pregnancy and Breastfeeding:
Pregnancy: Sabril may harm an unborn baby. If you are pregnant or planning to conceive, discuss the risks and benefits with your doctor.
Breastfeeding: It is unclear if Sabril passes into breast milk. Avoid breastfeeding unless advised by your doctor.

Possible Side Effects of Sabril 500 mg Tablets

Sabril (vigabatrin 500mg) can cause side effects, which vary in severity. Below is a concise description of potential side effects to help you understand what to expect.

Common Side Effects:

Drowsiness:

You may feel unusually tired or sleepy, which could affect daily activities.

Weight Gain:

Weight gain is a reported side effect in some individuals.

Dizziness:

Feeling lightheaded or unsteady may occur, especially when starting the medication.

Joint Pain:

Some patients experience discomfort in their joints.

Headache:

Mild to moderate headaches are possible during treatment.

Serious Side Effects:

Permanent Vision Loss:

Sabril can cause irreversible bilateral concentric visual field defects. Regular eye exams are required to monitor for this serious side effect.

You may not notice symptoms until significant damage has occurred.

Mental Health Changes:

Depression, anxiety, or mood swings.

Rarely, suicidal thoughts or behaviors. Inform your doctor immediately if these occur.

Seizure Worsening:

In rare cases, Sabril may worsen absence or myoclonic seizures. Notify your doctor if your seizures increase.

Neurological Symptoms:

Symptoms such as confusion, memory problems, or difficulty concentrating may develop in some individuals.

Rare Side Effects:

Peripheral Neuropathy:

Tingling or numbness in your hands or feet.

Skin Reactions:

Rash or itching may occur as an allergic reaction.

Abnormal Movements:

Some patients may experience tremors or involuntary movements.

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