Adcetris 50mg Injection (Brentuximab Vedotin)

Advetris 50mg Injetion contains (Brentuximab Vedotin) which is now available in Pakistan at Jasmeds. The price range of the Adcetris 50mg Injection is Rs 200,000 to Rs 300,000/-.

Product Description

Brand: Adcetris

Form: Injection

Packet Size: 1 Vial Injection

Active ingredient: Brentuximab Vedotin

Manufacturer: Tekeda

Treatment: Cancer

₨ 220,000

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Description

How Does Adcetris 50mg Injection Work?

Adcetris works by targeting a protein called CD30, which is found on some types of cancer cells. The medication is an antibody-drug conjugate, meaning it combines an antibody with a chemotherapy drug. The antibody part of Adcetris attaches to the CD30 protein on the cancer cells, and then the chemotherapy drug is released into the cells, killing them.

Adcetris is used to treat Hodgkin lymphoma and systemic anaplastic large cell lymphoma. It is given as an intravenous infusion.

How Should You Take Adcetris 50mg Injection?

Adcetris 50mg Injection (brentuximab vedotin) should be taken as follows:

Route: Administered as an intravenous (IV) infusion only.

Infusion Duration: The infusion should last for 30 minutes.

Frequency: Given every 3 weeks until disease progression or unacceptable toxicity occurs.

Reconstitution: Each 50 mg vial must be reconstituted with 10.5 mL of Sterile Water for Injection.

Gently swirl the vial to aid dissolution; do not shake.

Use a dedicated IV line for administration and do not mix with other medications.

Additional Details

Uses of the Adcetris 50mg Injection

Adcetris 50mg Injection, containing the active ingredient brentuximab vedotin, is primarily used in the treatment of specific types of lymphomas. Its applications include:

Classical Hodgkin Lymphoma: Adcetris is utilized for patients with this type of cancer, particularly those who have not received prior treatment or have relapsed after other therapies. It can be administered alone or in combination with other chemotherapy agents.

Cutaneous T-Cell Lymphoma: This medication is effective for treating certain forms of this non-Hodgkin lymphoma that affects the skin.

Systemic Anaplastic Large Cell Lymphoma (sALCL): Adcetris is indicated for adult patients with this aggressive form of lymphoma, especially in cases where the disease has returned or has not responded to previous treatments

Recommended Dosage of Adcetris 50mg Injection?

The recommended dosage of Adcetris 50mg Injection (brentuximab vedotin) is as follows:

For Adults with Relapsed Classical Hodgkin Lymphoma:

Dosage: 1.8 mg/kg (up to a maximum of 180 mg)

Frequency: Administered every 3 weeks as an intravenous infusion over 30 minutes until disease progression or unacceptable toxicity occurs.

For Previously Untreated Stage III or IV Classical Hodgkin Lymphoma:

Dosage: 1.2 mg/kg (up to a maximum of 120 mg) in combination with chemotherapy

Frequency: Administered every 2 weeks for a maximum of 12 doses, until disease progression or unacceptable toxicity.

For Consolidation Therapy Post-Auto-HSCT:

Dosage: 1.8 mg/kg (up to a maximum of 180 mg)

Frequency: Administered every 3 weeks, continuing until a maximum of 16 cycles, disease progression, or unacceptable toxicity.

Warnings and Precautions For Advertis 50mg Injection?

Adcetris 50mg Injection (brentuximab vedotin) comes with several warnings and precautions that must be considered before and during treatment:

Peripheral Neuropathy: Patients should be monitored for symptoms of neuropathy, such as tingling or weakness. Dose modifications may be necessary if symptoms worsen.

Anaphylaxis and Infusion Reactions: Serious infusion-related reactions, including anaphylaxis, can occur. If anaphylaxis is suspected, the infusion must be immediately discontinued, and appropriate medical treatment provided.

Hematologic Toxicities: Regular monitoring of complete blood counts is essential. Severe neutropenia (Grade 3 or 4) may require dose delays or reductions, and patients should be monitored for fever.

Infections: There is a risk of serious infections, including bacterial, fungal, and viral infections. Patients should be closely monitored for any signs of infection during treatment.

Tumor Lysis Syndrome: Patients with a high tumor burden may be at risk for tumor lysis syndrome and should be monitored closely.

Hepatotoxicity: Liver function tests should be conducted regularly as hepatotoxicity has been reported. Dose adjustments may be necessary for patients with hepatic impairment.

Pulmonary Toxicity: Monitor for new or worsening pulmonary symptoms, as pulmonary toxicity can occur.

Contraindications: Adcetris should not be used in combination with bleomycin due to the risk of pulmonary toxicity.

Possible Side Effects of Advertis 50mg Injection?

Adcetris 50mg Injection (brentuximab vedotin) may cause a variety of side effects, which can range from mild to severe. Here are the possible side effects:

Common Side Effects:

Fatigue: Up to 49% of patients may experience tiredness.

Nausea and Vomiting: Commonly reported, affecting a significant number of patients.

Peripheral Neuropathy: Symptoms include numbness, tingling, or burning sensations in the extremities.

Infections: Increased risk of upper respiratory infections and serious infections like pneumonia.

Weight Loss: Notable decrease in body weight may occur.

Muscle and Joint Pain: Discomfort in muscles and joints is frequently reported.

Serious Side Effects:

Anaphylaxis and Infusion Reactions: Severe allergic reactions can occur, including difficulty breathing and rash.

Progressive Multifocal Leukoencephalopathy (PML): A rare but serious brain infection that can lead to disability or death.

Hematologic Toxicities: Low blood cell counts, including neutropenia and thrombocytopenia, increasing the risk of bleeding and infections.

Liver Toxicity: Elevated liver enzymes indicating potential liver damage.

Hyperglycemia: Increased blood sugar levels leading to symptoms like increased thirst and urination.

Gastrointestinal Symptoms: Diarrhea, constipation, and abdominal pain may occur.

Skin Reactions: Rash, itching, or severe skin reactions (DRESS syndrome) can develop.

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Adcetris 50mg Injection (Brentuximab Vedotin)

Description

How Does Adcetris 50mg Injection Work?

How Should You Take Adcetris 50mg Injection?

Additional Details

Uses of the Adcetris 50mg Injection

Recommended Dosage of Adcetris 50mg Injection?

Warnings and Precautions For Advertis 50mg Injection?

Possible Side Effects of Advertis 50mg Injection?

Customer Reviews

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