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Rhophylac IM/IV Inj 300mcg 1x2ml Injection

Rhophylac 10mg Tablet contains (Rho (D) Immune Globulin) which is now available in Pakistan at Jasmeds. The price range of the Rhophylac 300mcg injection is Rs 10,000/- to Rs 15,000/-.

Product Description

Brand: Rhophylac
Form: Injection
Packet Size: 1’s Prefilled Syringe
Active ingredient: Human anti-d immunoglobulin
Manufacturer: Behring/Hakimsons
Treatment: mother’s immune system from developing antibodies during Pregnancy.

 13,000

Description

How Does Rhophylac 300mcg Injection Work? 

Rhophylac 300mcg Injection works by providing passive immunity against tetanus.

Passive Immunity: This means that Rhophylac contains antibodies that are specifically designed to fight the tetanus toxin. These antibodies are produced in horses and then purified for human use.

How it Works: When you receive a Rhophylac injection, these pre-formed antibodies are introduced directly into your bloodstream. These antibodies can quickly neutralize the tetanus toxin, preventing it from causing the serious complications of tetanus, such as muscle spasms and paralysis.

How Should You Take Rhophylac 300mcg Injection?

The Rhophylac 300mcg Injection is administered by a healthcare professional to ensure proper dosage and technique. It is given either as an intramuscular (IM) injection or an intravenous (IV) injection, depending on your medical needs and circumstances.

During Pregnancy: If you are Rh-negative and your doctor has determined that your baby may be Rh-positive, Rhophylac is typically administered at 28 weeks of pregnancy. A second dose is given within 72 hours after childbirth if your baby is confirmed to be Rh-positive.

After Events with Blood Mixing: If you experience a miscarriage, abortion, ectopic pregnancy, or any other event that may cause Rh-positive blood cells to enter your system, Rhophylac should be administered within 72 hours.

Additional Details

Uses of the Rhophylac 300mcg Injection

The Rhophylac 300mcg Injection is primarily used to prevent Rh immunization in Rh-negative individuals exposed to Rh-positive blood. This exposure can occur during pregnancy, childbirth, miscarriage, abortion, or blood transfusion. Rhophylac contains human anti-D immunoglobulin (Rho(D) immune globulin), which helps suppress the immune response to Rh-positive blood cells in Rh-negative individuals.

For Pregnant Individuals: If you are Rh-negative and your baby is Rh-positive, Rhophylac prevents your immune system from producing antibodies that could harm your baby in current or future pregnancies. It is typically administered at 28 weeks of pregnancy and within 72 hours after childbirth if the baby is confirmed Rh-positive.

After a Miscarriage or Abortion: Rhophylac is used to prevent sensitization in Rh-negative individuals within 72 hours of the event.

For Blood Transfusions or Trauma: If you receive Rh-positive blood or experience significant trauma (e.g., abdominal injury during pregnancy), Rhophylac reduces the risk of complications by neutralizing Rh-positive red blood cells.

During Medical Procedures: If you undergo procedures like amniocentesis, chorionic villus sampling, or external cephalic version, Rhophylac can be given to protect against Rh sensitization.

Warnings and Precautions of Rhophylac 300mcg Injection

Before taking the Rhophylac 300mcg Injection, it is essential to be aware of specific warnings and precautions to ensure its safe and effective use. This injection is administered under medical supervision and should not be self-administered.

Warnings:

Severe Allergic Reactions:

Rhophylac may cause severe hypersensitivity reactions, including anaphylaxis. If you have a known allergy to human immunoglobulins or any ingredient in the injection, inform your doctor immediately.

Blood Clot Risk:

Rarely, Rhophylac may increase the risk of thromboembolic events (blood clots), particularly in patients with pre-existing conditions like immobility, cardiovascular disease, or coagulation disorders.

Hemolysis (Red Blood Cell Breakdown):

In individuals with immune thrombocytopenia purpura (ITP), Rhophylac may cause intravascular hemolysis, leading to complications such as anemia or hemoglobinuria.

Transmission of Infections:

Since Rhophylac is derived from human plasma, there is a very minimal risk of transmitting infections, although rigorous screening and processing significantly reduce this risk.

Not for Rh-Positive Individuals:

Rhophylac is not intended for use in individuals who are Rh-positive, as it will have no therapeutic benefit and may cause adverse effects.

Precautions

Medical History and Conditions:

Inform your doctor if you have a history of allergies, immunodeficiency, or autoimmune disorders. Mention any chronic conditions like liver disease, as Rhophylac may affect liver function in rare cases.

Pregnancy and Breastfeeding:

While Rhophylac is widely used in pregnant individuals, it should only be administered under medical supervision. No significant risks to breastfeeding infants have been reported, but you should inform your doctor if you are nursing.

Vaccinations:

Rhophylac may interfere with the effectiveness of live vaccines (e.g., measles, mumps, rubella). Wait at least 3 months after Rhophylac administration before receiving live vaccines.

Possible Side Effects of Rhophylac 300mcg Injection

The Rhophylac 300mcg Injection is generally safe when administered under medical supervision, but like any medication, it may cause side effects in some individuals. These effects are typically mild and temporary but can occasionally be severe.

Common Side Effects:

  • Injection Site Reactions:
      1. Pain, redness, swelling, or tenderness at the injection site.
      2. These are mild and typically resolve within a few days.
  • General Discomfort:
      1. Fatigue or weakness.
      2. Low-grade fever or chills.
  • Headache:
      1. Mild to moderate headaches may occur after administration.
  • Nausea:
    1. Some individuals may experience an upset stomach or nausea.

Less Common but Serious Side Effects:

  • Allergic Reactions:
      1. Symptoms may include:
        1. Rash or itching.
        2. Difficulty breathing or wheezing.
        3. Swelling of the face, lips, tongue, or throat (angioedema).
      2. Severe allergic reactions (anaphylaxis) are rare but require immediate medical attention.
  • Hemolysis (Red Blood Cell Breakdown):
      1. In rare cases, particularly in individuals with immune thrombocytopenia purpura (ITP), Rhophylac can cause hemolysis. Symptoms may include:
        1. Dark-colored urine.
        2. Back pain.
        3. Pale skin or jaundice.
  • Blood Clots (Thromboembolism):
    1. Rarely, blood clots may form, particularly in individuals with underlying conditions such as immobility or cardiovascular disease. Symptoms include:
      1. Swelling or pain in the legs.
      2. Chest pain or shortness of breath.

Rare Side Effects:

  • Dizziness or Lightheadedness:
      1. May occur immediately after the injection, particularly if administered intravenously.
  • Hypotension (Low Blood Pressure):
      1. A temporary drop in blood pressure might happen, often accompanied by dizziness.
  • Flu-like Symptoms:
    1. Muscle aches, joint pain, or general malaise may occur after the injection.
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