What is a Hilvel 400/100mg Tablet?

Hilvel 400/100mg Tablet is a combination of two antiviral medicines: Sofosbuvir and Velpatasvir. Sofosbuvir is an HCV NS5B polymerase inhibitor. Velpatasvir is an HCV NS5A inhibitor.

What Should You Do If You Take an Overdose of Hilvel 400/100mg Tablet?

If you suspect an overdose of Hilvel 400/100mg Tablets, seek immediate medical attention. Call your local poison control center or go to the nearest emergency room right away.

Can Kidney Patients Use Hilvel 400/100mg Tablet?

Yes, Patients with kidney disease, particularly those with end-stage renal disease (ESRD) undergoing dialysis, can use Hilvel 400/100mg tablets, which contain Sofosbuvir and Velpatasvir. Studies have shown that treatment with Sofosbuvir and Velpatasvir is effective in patients with chronic hepatitis C virus (HCV) infection who are on hemodialysis or peritoneal dialysis. A notable study reported a sustained virologic response (SVR) rate of approximately 95% among patients treated for 12 weeks with this combination therapy.

Can I Take a Hilvel 400/100mg Tablet Before Driving?

Yes, you can take Hilvel 400/100 mg before driving, but proceed with caution. The tablet may cause side effects like dizziness or fatigue in some people, which could impair your ability to drive safely. If you experience these symptoms, avoid driving. Monitor how the medication affects you before deciding to drive.

How Long is the treatment for Hilvel 400/100mg Tablet?

The treatment duration for Hilvel 400/100mg tablets is typically 12 weeks for adults. This regimen is used to effectively treat chronic hepatitis C virus (HCV) infections. In some cases, the treatment duration may vary based on individual patient factors, so it is essential to follow your healthcare provider's recommendations.

Can I Buy Hilvel 400/100mg Tablets Online in Pakistan?

Yes, you can buy hilvel 400/100mg Tablets online in Pakistan from Jasmeds. which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

What Medicines Should I Avoid When Taking Hilvel 400/100mg Tablets?

Medicines to Avoid Amiodarone: This medication can lead to serious side effects, such as bradycardia (slow heart rate) or cardiac arrest, especially in patients with heart disease or advanced liver disease. Rifampin: This antibiotic can significantly reduce the effectiveness of Hilvel by decreasing its plasma concentrations. Elagolix: Avoid using this medication as it may interact negatively with Hilvel. Grazoprevir: This combination may not be recommended due to potential interactions. Levoketoconazole: Similar to the above, this medication should be avoided. St. John’s Wort: An herbal supplement that can significantly affect the metabolism of Hilvel, potentially reducing its effectiveness. Phenobarbital: Used for seizures, this medication may also interact with Hilvel and should be discussed with your healthcare provider. Digoxin: While not strictly contraindicated, caution is advised as it may increase the risk of certain side effects when used with Hilvel.

What foods should I avoid while taking a Hilvel 400/100mg Tablet?

The foods that you should avoid while taking a Hilvel 400/100mg tablet are Grapefruit and grapefruit juice, High-fat meals, Alcohol and Antacids.

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Hilvel 400/100mg Tablets (Sofosbuvir)

Hilvel contains Sofosbuvir which is now available in Pakistan at Jasmeds. The price range of the Hilvel Tablet is Rs 10,000/- to Rs 15,000/-.

Product Description

Brand: Hilvel
Form: Tablets
Strength: 400mg (Sofosbuvir) + 100mg (Velpatasvir
Size: 28’s Capsules
Active Ingredient: Sofosbuvir + Velpatasvir
Manufacturer: Hilton Pharma
Treatment: Chronic Hepatitis C Virus (HCV) infection

Original price was: ₨ 13,500.Current price is: ₨ 12,500.

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Description

Uses of the Hilvel 400/100mg 28’s Tablets

Hilvel 400/100mg tablets are primarily used for the treatment of chronic hepatitis C virus (HCV) infections. Here’s a detailed overview of its uses:

Treatment of Chronic Hepatitis C: Hilvel is indicated for adults with chronic HCV infection, effective against various genotypes, including 1, 2, 3, 4, 5, and 6. This makes it a versatile option for patients with different strains of the virus.

Patients with or without Cirrhosis: It is suitable for use in patients regardless of the presence of cirrhosis. This includes both those with compensated cirrhosis and those without liver damage.

Combination Therapy: Hilvel is often used in combination with other antiviral agents to enhance treatment efficacy. This combination approach helps in achieving better outcomes in managing hepatitis C.

Liver Transplantation: The medication may also be utilized in the context of liver transplantation to prevent recurrence of hepatitis C post-transplant.

Hepatocellular Carcinoma: In some cases, Hilvel is prescribed for patients with hepatocellular carcinoma (a type of liver cancer), particularly when associated with chronic hepatitis C.

Additional Details

How Does Hilvel 400/100mg Tablet Works?

Hilvel 400/100mg 28’s Tablets contain two active ingredients that work together to fight hepatitis C virus (HCV) infection:

Sofosbuvir: This component inhibits an enzyme called NS5B RNA polymerase. This enzyme is crucial for the hepatitis C virus to multiply. By blocking it, sofosbuvir effectively stops the virus from replicating.

Velpatasvir: This component targets an HCV protein called NS5A, which is also essential for viral replication. By blocking NS5A, velpatasvir disrupts the virus’s ability to make copies of itself.

This dual action of sofosbuvir and velpatasvir, attacking the virus at two different stages of its life cycle, makes Hilvel 400/100mg 28’s Tablets highly effective in treating HCV infection.

How Should You Take Hilvel 400/100mg Tablet?

To ensure safe and effective treatment with Hilvel 400/100mg Tablets, it’s crucial to follow your doctor’s instructions precisely. Here are some general guidelines on how to take Hilvel 400/100mg Tablets:

Take it orally: Hilvel 400/100mg 28’s Tablets should be swallowed whole with a full glass of water. Do not crush, chew, or break the tablet.

Take it with or without food: Hilvel 400/100mg 28’s Tablets can be taken with or without food.

Take it for the full course of treatment: It is important to complete the full course of treatment with Hilvel 400/100mg 28’s Tablets, even if you feel better. Stopping treatment early may increase the risk of the virus returning.

Do not miss doses: Try to take Hilvel 400/100mg 28’s Tablets at the same time each day. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.

Recommended Dosage of Hilvel 400/100mg Tablet

The recommended dosage for Hilvel 400/100mg tablets, which contain Sofosbuvir and Velpatasvir, is as follows:

For Adults:

Dosage: Take one tablet (400 mg Sofosbuvir and 100 mg Velpatasvir) orally once a day.

Duration of Treatment: Typically, the treatment lasts for 12 weeks.

Pediatric Patients (3 years and older):

Weight at least 30 kg: One tablet (400 mg Sofosbuvir and 100 mg Velpatasvir) once a day for 12 weeks.

Weight between 17 kg and less than 30 kg: One tablet (200 mg Sofosbuvir and 50 mg Velpatasvir) once a day for 12 weeks.

Weight less than 17 kg: Use of oral pellets is recommended, with the specific dosage determined by a healthcare provider.

Warnings and Precautions of Hilvel 400/100mg Tablets

When using Hilvel 400/100mg tablets, it is important to be aware of various warnings and precautions to ensure safe and effective treatment. Here are the key considerations:

Allergic Reactions: Inform your healthcare provider if you have a history of allergies to Sofosbuvir, Velpatasvir, or any other components of the medication. Hypersensitivity reactions can occur.

Liver Disease: Use Hilvel with caution in patients with advanced liver disease (decompensated cirrhosis). The risk of bradycardia (slow heart rate) may increase in these patients.

Hepatitis B Reactivation: If you have a history of hepatitis B infection or are co-infected with hepatitis C, there is a risk that the hepatitis B virus could reactivate during treatment. Testing for hepatitis B should be conducted before starting Hilvel.

Heart Conditions: Patients with existing heart disease should use Hilvel cautiously, particularly if they are also taking amiodarone, as this combination can lead to serious cardiac issues such as bradycardia or cardiac arrest.

Drug Interactions:

Avoid using Hilvel in conjunction with certain medications, including:

Amiodarone: Increases the risk of severe cardiovascular side effects.

Ribavirin: Can cause birth defects; effective contraception is necessary during treatment and for at least 6 months afterward.

Other drugs that may interact include digoxin and certain herbal supplements like St. John’s Wort.

Pregnancy and Breastfeeding:

Consult your healthcare provider if you are pregnant or planning to become pregnant while on Hilvel. Ribavirin, when used in combination with Hilvel, poses risks of birth defects.

The safety of Hilvel during breastfeeding has not been established; consult your doctor before breastfeeding.

Pediatric Use: Safety and efficacy in children younger than 3 years have not been established. Use in children aged 3 years and older should be monitored closely.

Possible Side Effects of Hilvel 400/100mg Tablets

Taking Hilvel 400/100mg tablets may lead to various side effects. Here’s a detailed overview of the possible side effects associated with this medication:

Common Side Effects:

Headache: A frequent complaint among users, headaches can occur during treatment.

Fatigue or Tiredness: Many patients report feeling unusually tired or weak.

Nausea: Some individuals may experience feelings of nausea, which can sometimes lead to vomiting.

Insomnia: Difficulty sleeping is another common issue reported by patients.

Diarrhea: Loose stools can occur as a side effect of the medication.

Less Common Side Effects

Anorexia: A loss of appetite can be experienced.

Weight Loss: Some patients may notice unintended weight loss during treatment.

Irritability or Mood Changes: Feelings of irritability or mood swings may arise.

Lack of Interest or Pleasure: Some individuals might experience a decrease in interest in activities they usually enjoy.

Serious Side Effects (Seek Immediate Medical Attention):

Difficulty breathing or wheezing

Swelling of the face, lips, tongue, or throat

Hives or rash

Dizziness or lightheadedness

Hepatitis B Reactivation: In patients with a history of hepatitis B, there is a risk that the virus could reactivate during treatment. Symptoms may include:

Right-sided abdominal pain

Vomiting

Loss of appetite

Yellowing of the skin or eyes (jaundice)

Bradycardia (Slow Heart Rate): Particularly when taken with amiodarone, watch for symptoms like fainting, dizziness, and chest pain.

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