What is a Xolair 150mg Injection?

Xolair is a monoclonal antibody that targets immunoglobulin E (IgE), a protein involved in allergic reactions.

Can I Buy Xolair 150mg injection Online in Pakistan?

Yes, you can buy Xolair 150mg injection from Jasmeds, which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

What Should You Do If You Take an Overdose of Xolair 150mg Injection?

If you suspect an overdose of Xolair 150mg Injection, seek immediate medical attention. Call your local emergency number (such as 911 in the US) or go to the nearest emergency room. Stay calm: It's important to remain calm and assess the situation. Call for help: Immediately call your local emergency number or contact a poison control center. They can provide guidance on how to proceed. Gather information: If possible, gather information about the medication, such as the amount taken, the time of ingestion, and any other relevant details. This information can be helpful to medical professionals. Follow instructions: Follow the instructions provided by emergency responders or medical professionals. They may advise you to stay with the person who overdosed and monitor their condition until help arrives.

Does Xolair 150mg Injection Affect Kidney Patients?

Yes, Xolair 150mg Injection can affect kidney patients. There have been no specific studies on the effect of impaired renal function on the pharmacokinetics of omalizumab (the active ingredient in Xolair).

Can I Take Xolair 150mg Injection Before Driving?

Yes, It is generally safe to drive after receiving a Xolair 150mg injection.

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Xolair 150mg Injection Solution (Omalizumab)

Xolair 150mg injection contains omalizumab which is now available in Pakistan at Jasmeds. The price range of the Xolair 20mg injection is Rs.35,000/- to Rs.65,000/-.

Product Description

Brand: Xolair
Packet Size: 1’s injection
Active ingredient: omalizumab
Manufacturer: Novartis
Treatment: Allergic asthma

₨ 50,000

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Description

How Does Xolair 150mg Injection Work?

Xolair 150 mg Injection (omalizumab) works primarily by targeting and inhibiting immunoglobulin E (IgE), a key mediator in allergic responses. Here’s a concise explanation of its mechanism of action:

IgE Binding: Xolair is a humanized monoclonal antibody that selectively binds to free IgE in the bloodstream. By doing so, it prevents IgE from attaching to its high-affinity receptor, FcεRI, located on the surface of mast cells and basophils.

Reduction of Allergic Response: This inhibition reduces the activation of these immune cells and limits the release of inflammatory mediators (such as histamines and cytokines) that contribute to allergic reactions and asthma symptoms.

Decrease in Free IgE Levels: Treatment with Xolair leads to a significant reduction in serum free IgE levels, often exceeding 95%, which helps decrease the overall allergic response in patients with conditions like allergic asthma and chronic spontaneous urticaria.

Long-term Effects: The reduction in free IgE also results in decreased expression of FcεRI receptors on basophils, further diminishing the potential for allergic reactions over time.

How Should You Take Xolair 150mg Injection?

To take Xolair 150 mg Injection (omalizumab) correctly, follow these guidelines:

Use a new 3 mL syringe with an 18-gauge needle to withdraw the solution from the vial.

Replace the 18-gauge needle with a 25-gauge needle for injection.

Ensure the total volume is adjusted to deliver either 150 mg (1.2 mL) or 75 mg (0.6 mL) as prescribed.

Choose an injection site in the front of the thigh or lower abdomen, avoiding areas around the belly button and any skin that is tender or bruised.

If multiple injections are needed, ensure they are at least 2 cm apart.

Clean the injection site with an alcohol wipe and allow it to dry.

Pinch the skin to elevate it and insert the needle at a 45-degree angle.

Slowly press the plunger to inject the solution over 5-10 seconds.

After injecting, remove the needle and apply gentle pressure to the site if needed.

Dispose of needles and syringes safely.

Additional Details

Uses of the Xolair 150mg Injection

Xolair 150 mg Injection (omalizumab) is used for several allergic conditions. Here are its primary uses:

Moderate to Severe Persistent Asthma: Xolair is indicated for adults and children aged 6 years and older with moderate to severe persistent asthma that is inadequately controlled with inhaled corticosteroids and who have a positive skin test or in vitro reactivity to perennial aeroallergens.

Chronic Spontaneous Urticaria (CSU): It is used in adults and adolescents aged 12 years and older who remain symptomatic despite treatment with antihistamines.

IgE-Mediated Food Allergies: Xolair is indicated for reducing the risk of severe allergic reactions (anaphylaxis) in individuals aged 1 year and older who have IgE-mediated food allergies. It should be used alongside strict avoidance of the allergen.

Chronic Rhinosinusitis with Nasal Polyps: For adults aged 18 years and older, Xolair serves as add-on therapy for chronic rhinosinusitis with nasal polyps when nasal corticosteroids have not been effective.

Recommended Dosage of Xolair 150mg Injection?

The recommended dosage of Xolair 150 mg Injection (omalizumab) varies based on the condition being treated, body weight, and serum total IgE levels. Here’s a concise overview:

For Chronic Spontaneous Urticaria (CSU):

Dosage: 150 mg or 300 mg administered subcutaneously every 4 weeks.

Note: The dosage for CSU is not dependent on serum IgE levels or body weight.

For Allergic Asthma

Dosage Range: 75 mg to 375 mg administered subcutaneously every 2 or 4 weeks.

Determination: The specific dose is based on:

Body weight (kg)

Serum total IgE level (IU/mL) measured before treatment.

For Chronic Rhinosinusitis with Nasal Polyps (CRSwNP):

Dosage: Typically, 300 mg every 4 weeks, but may vary based on individual assessment.

For IgE-Mediated Food Allergies:

Dosage: Determined similarly to asthma, with specific dosing based on body weight and IgE levels.

Warnings and Precautions of Xolair 150mg Injection

Xolair 150 mg Injection (omalizumab) has several important warnings and precautions that users should be aware of:

Anaphylaxis Risk: There is a significant risk of anaphylaxis, which can manifest as bronchospasm, hypotension, urticaria, and/or angioedema. Anaphylaxis can occur after the first dose or even after prolonged treatment. Patients should be monitored closely in a healthcare setting for a period following administration, and healthcare providers should be prepared to manage severe allergic reactions.

Severe Allergic Reactions: Patients with a known hypersensitivity to omalizumab or any of its components should not use Xolair. It is crucial to inform patients about the signs of severe allergic reactions and instruct them to seek immediate medical help if symptoms occur.

Cancer Risk: There have been reports of malignancies in patients receiving Xolair. Patients should be informed about this potential risk, particularly regarding certain types of cancers.

Infection Risks: Xolair may increase the risk of infections, particularly parasitic infections in individuals living in or traveling to endemic areas. Patients should be aware of symptoms indicating infection and report them promptly.

Use in Specific Populations: Caution is advised when prescribing Xolair to patients with a history of heart attack, stroke, or those receiving allergy shots. Its safety has not been established in children under 6 years or adolescents under 18 for certain indications.

Possible Side Effects of Xolair 150mg Injection

Xolair 150 mg Injection (omalizumab) may cause a variety of side effects, ranging from common to serious. Here’s a concise overview:

Common Side Effects:

Injection Site Reactions: Pain, redness, swelling, or irritation at the injection site.

Headache: Frequent occurrence post-injection.

Dizziness: May affect balance and coordination.

Joint Pain: Discomfort in arms or legs.

Fever: Commonly reported, especially in children.

Nausea and Vomiting: Gastrointestinal disturbances.

Upper Respiratory Infections: Symptoms like sore throat, nasal congestion, or sinusitis.

Fatigue: General tiredness or weakness.

Serious Side Effects

Severe Allergic Reactions: Symptoms include hives, difficulty breathing, swelling of the face or throat, and anaphylaxis. This can occur even after prolonged use.

Cancer Risk: There have been rare reports of malignancies associated with Xolair use; the relationship is not clearly established.

Parasitic Infections: Symptoms may include abdominal pain and diarrhea.

Cardiovascular Issues: Possible heart attack, stroke, or blood clots; symptoms include chest pain, weakness on one side of the body, or sudden vision changes.

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