Velso contains sofosbuvir which is now available in Pakistan at Jasmeds. The price range of the Epclusa tablet is Rs 5,000/- to Rs 10,000/-.
Product Description
Brand: Velso
Form: Tablet
Strength: 400/100 mg
Size: 28’s Tablets
Active Ingredient: Sofosbuvir + Velpatasvir
Manufacturer: Genix
Original price was: ₨ 10,000.₨ 9,500Current price is: ₨ 9,500.
You can use Velso for:
Treating chronic HCV infections of genotypes 1, 2, 3, 4, 5, or 6.
Patients without cirrhosis or with compensated cirrhosis.
Patients with decompensated cirrhosis when used alongside ribavirin.
Velso 400/100 mg Tablets work through a combination of two potent antiviral agents: Sofosbuvir and Velpatasvir. Each component plays a critical role in inhibiting the hepatitis C virus (HCV) replication process.
Sofosbuvir
Type: Nucleotide analog NS5B polymerase inhibitor.
Function: Sofosbuvir is converted into its active form within the body, which then incorporates itself into the viral RNA during replication. This action effectively terminates the viral RNA chain, preventing further replication of the virus.
Velpatasvir
Type: NS5A inhibitor.
Function: Velpatasvir interferes with the NS5A protein, which is essential for HCV replication and assembly. By binding to the NS5A protein, it disrupts the virus’s ability to replicate and assemble properly.
With or Without Food: You can take the tablet with or without food.
Swallow Whole: Swallow the tablet whole; do not crush, break, or chew it to avoid a bitter taste.
Antacids: If you are taking antacids that contain aluminum or magnesium, ensure you take them at least 4 hours before or after taking Velso.
Consistency: It is important to take Velso at the same time every day to maintain a steady level of the medication in your body. Continue taking the medication for the full prescribed duration, even if you start feeling better before completing the course.
Missed Dose: If you miss a dose and remember it within 18 hours, take it as soon as possible. If it’s been more than 18 hours, skip the missed dose and resume your regular schedule.
Vomiting: If you vomit within 3 hours of taking the tablet, take the same dose again.
Food Considerations: Take the tablet on an empty stomach or at least 1-2 hours after a meal. Food may increase the risk of certain side effects, such as nausea.
The recommended dosage for Velso 400/100 mg Tablets is as follows:
For Adults
Dosage: Take one tablet (400 mg Sofosbuvir and 100 mg Velpatasvir) once daily.
Duration: The typical treatment duration is 12 weeks. In certain cases, it may be extended to 24 weeks, especially for patients with specific conditions such as decompensated cirrhosis when used in combination with ribavirin.
For Pediatric Patients
Age: Not recommended for children under 3 years.
Weight-Based Dosage:
For children weighing at least 30 kg: One tablet (400 mg/100 mg) once daily.
For children weighing 17 to less than 30 kg: Sofosbuvir 200 mg and Velpatasvir 50 mg once daily.
For children weighing less than 17 kg: Sofosbuvir 150 mg and Velpatasvir 37.5 mg once daily.
Before taking Velso 400 mg Tablets, it’s essential to be aware of the following warnings and precautions to ensure your safety and the effectiveness of the treatment:
Velso may cause liver problems. Inform your doctor if you have a history of hepatitis B, hepatitis C, or other liver conditions.
Regular liver function tests are recommended during treatment.
This medication may cause dizziness, mood changes, or depression. Inform your doctor if you experience unusual thoughts, anxiety, or difficulty sleeping.
Use caution if you have a history of mental health disorders, including suicidal thoughts.
Rare but severe allergic reactions, such as rash, fever, or swelling, may occur. Seek immediate medical attention if you notice these symptoms.
Avoid Velso if you are pregnant or planning to become pregnant, as it may harm the baby.
Do not breastfeed while on Velso, as HIV can pass through breast milk.
Use with caution if you have a history of seizures. Inform your doctor of any conditions or medications that may affect seizure risk.
Velso may interact with other medications, including anticonvulsants, antifungals, or hormonal contraceptives.
Inform your doctor about all the medications, supplements, and herbal products you are taking.
This medication may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how it affects you.
In some cases, your immune system may become overactive, leading to new or worsening symptoms of infections. Report any unusual symptoms to your doctor.
Avoid prolonged exposure to sunlight or UV light, as Velso may increase your skin’s sensitivity. Use sunscreen and wear protective clothing.
Do not stop taking Velso without your doctor’s approval, as this can lead to viral resistance and worsen your condition.
While Velso 400 mg Tablets are effective in managing HIV, they may cause side effects. Below are the potential side effects categorized by their frequency and severity:
Common Side Effects (May Affect 1 in 10 People)
Dizziness
Headache
Nausea
Vomiting
Trouble sleeping (insomnia)
Fatigue
Rash
Diarrhea
Uncommon Side Effects (May Affect 1 in 100 People)
Mood changes (e.g., anxiety, depression)
Nightmares or vivid dreams
Loss of appetite
Itching or hives
Fever
Rare Side Effects (May Affect 1 in 1,000 People)
Severe skin reactions (e.g., Stevens-Johnson syndrome)
Liver problems (e.g., yellowing of the skin or eyes, dark urine)
Seizures
Severe allergic reactions (e.g., swelling of the face, lips, or throat)
Serious Side Effects (Seek Immediate Medical Attention)
Mental health issues: Suicidal thoughts, severe mood swings, or hallucinations.
Immune reconstitution syndrome: Symptoms of new or worsening infections as your immune system recovers.
Signs of liver damage: Persistent nausea, stomach pain, jaundice.
What to Do If You Experience Side Effects
Mild side effects (e.g., nausea, headache): Usually subside as your body adjusts to the medication.
Severe or persistent side effects: Contact your healthcare provider immediately.
