Tygacil 50mg 1 Vial Injection (Tigecycline)

Tygacil 50mg tablet contains (Tigecycline) which is now available in Pakistan at Jasmeds. The price range of the Tygacil 50mg Tablet is Rs 15,000 to Rs 30,000/-. 

Product Description 

Brand: Tygacil
Form: Injection
Packet Size: 1 Vial
Active ingredient: (Tigecycline)
Manufacturer: Wyeth Pharmaceuticals Pvt Ltd
Treatment: Bacterial infections

 23,000

Description

How Does Tygacil 50mg Injection Work?

Tygacil 50 mg Injection, containing the active ingredient Tigecycline, works primarily by inhibiting bacterial protein synthesis. It binds to the 30S ribosomal subunit of bacteria, blocking the entry of aminoacyl-tRNA into the ribosome’s A site. This action prevents the incorporation of amino acids into peptide chains, effectively halting protein production and inhibiting bacterial growth.

Tigecycline is classified as a glycylcycline antibiotic, which allows it to overcome common resistance mechanisms seen with other tetracyclines. Its unique structure enhances its binding affinity to the ribosome, making it effective against a broad range of Gram-positive and Gram-negative bacteria, including those resistant to multiple drugs .

This mechanism makes Tygacil particularly useful for treating serious infections where other antibiotics may fail.

How Should You Take Tygacil 50mg Injection? 

Tygacil 50mg Injection is administered by a healthcare professional as an intravenous (IV) infusion, usually over 30 to 60 minutes. The dosage and duration of treatment depend on the type and severity of the infection.

It is essential to follow your doctor’s instructions and not skip any doses to ensure the infection is fully treated. Inform your doctor about any other medications or allergies before starting Tygacil. 

Additional Details

Uses of the Tygacil 50mg Injection 

Tygacil 50 mg Injection is an antibiotic used to treat various bacterial infections. It contains the active ingredient Tigecycline, which is effective against serious infections such as: 

Complicated skin and skin structure infections 

Intra-abdominal infections 

Community-acquired pneumonia (lung infection) 

Warnings and Precautions of Tygacil 50mg Injection

Tygacil 50 mg Injection comes with several important warnings and precautions: 

Increased Mortality Risk: There is a noted increase in all-cause mortality among patients treated with Tygacil compared to those receiving other antibiotics. This has been observed in clinical trials, although the exact cause is not fully understood. Patients should discuss the risks and benefits with their healthcare provider before starting treatment  

Pregnancy and Breastfeeding: Tygacil should not be used during pregnancy as it may harm the unborn baby and can lead to permanent tooth discoloration in children. Effective birth control is recommended during treatment, and breastfeeding should be discussed with a doctor  

Allergic Reactions: Patients with known hypersensitivity to tigecycline or tetracycline antibiotics may experience severe allergic reactions, including anaphylaxis. Caution is advised for these individuals  

Liver Function: Tygacil can cause liver dysfunction and failure. Patients with pre-existing liver conditions should be closely monitored during treatment  

Drug Interactions: Certain medications should not be administered through the same IV line as Tygacil, including amphotericin B and diazepam. It is important to inform healthcare providers of all medications being taken to avoid interactions  

Sun Sensitivity: Tygacil may increase sensitivity to sunlight, leading to a higher risk of sunburn. Patients are advised to wear protective clothing and use sunscreen while outdoors  

Diarrhea Warning: Antibiotics like Tygacil can cause diarrhea, which may indicate a new infection. If diarrhea is watery or bloody, medical attention should be sought immediately. 

Possible Side Effects of Tygacil 50mg Injection

Possible side effects of Tygacil 50 mg Injection include both common and serious reactions: 

Common Side Effects 

  • Nausea 
  • Vomiting 
  • Stomach pain 
  • Diarrhea 
  • Headache 
  • Dizziness 
  • Pain or swelling at the injection site 

These side effects are generally mild and may resolve as the body adjusts to the medication. 

Serious Side Effects 

Seek immediate medical attention if you experience any of the following: 

Allergic Reactions: Symptoms may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. 

Severe Diarrhea: Watery or bloody stools that may occur during or after treatment. 

Increased Pressure in the Brain: Severe headache, ringing in the ears, dizziness, nausea, vision problems, or pain behind the eyes. 

Pancreatitis: Severe upper stomach pain that spreads to the back, along with nausea and vomiting. 

Liver Problems: Symptoms such as nausea, upper stomach pain, itching, fatigue, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). 

FAQ's

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