Lonsurf 15mg/6.14mg Tablet (Tipiracil)

Lonsurf 15mg Tablet contains (Tipiracil) which is now available in Pakistan at Jasmeds. The price range of the Lonsurf 15mg Tablet is Rs 100,000 to Rs 300,000/-.

Product Description

Brand: Lonsurf
Form: Tablets
Packet Size: 60’s Tablets
Active ingredient: tipiracil and trifluridine
Manufacturer: Taiho Oncology, Inc.
Treatment: Stomach Cancer

 280,000

Description

How Does Lonsurf 15mg Tablet? 

Trifluridine: A cytotoxic agent that gets incorporated into the DNA of cancer cells, disrupting their replication and growth.

Tipiracil: Inhibits the enzyme that breaks down trifluridine, ensuring higher levels of the drug remain in the body for effective cancer treatment.

How Should You Take Lonsurf 15mg Tablet?

Take the tablets twice daily (morning and evening) for 5 consecutive days, followed by 2 days off.

This pattern is repeated for 2 weeks, followed by a 14-day rest period to complete a 28-day treatment cycle.

Take Lonsurf with food and a full glass of water to reduce the risk of nausea and improve absorption.

Swallow the tablets whole. Do not crush, chew, or break them.

Take the doses at the same time each day to maintain consistent levels of the medication in your body.

Avoid missing doses. If you forget a dose, skip it and take the next dose as scheduled. Do not double the dose to make up for a missed one.

Additional Details

Uses of the Lonsurf 15mg Tablets

Lonsurf 15mg Tablets contain two active ingredients, trifluridine and tipiracil, and are primarily used to treat certain types of cancer. It is a combination chemotherapy medication prescribed for the management of advanced or metastatic cancer when other treatment options are no longer effective.

Lonsurf is used for patients with metastatic colorectal cancer (colon or rectal cancer that has spread to other parts of the body) who have previously been treated with or are not candidates for other therapies, such as fluoropyrimidine, oxaliplatin, and irinotecan-based chemotherapy.

Lonsurf is also approved for treating metastatic gastric cancer (stomach cancer that has spread) or gastroesophageal junction cancer in patients who have not responded to prior treatments.

Warnings and Precautions For Lonsurf 15mg Tablet?

Lonsurf (trifluridine and tipiracil) is a prescription medication used to treat certain types of cancer. Here are some important warnings and precautions:   

Serious Warnings:

Low Blood Counts: Lonsurf can significantly decrease your blood cell counts, including white blood cells, red blood cells, and platelets. 

Low white blood cells increase your risk of serious infections.   

Low red blood cells can cause anemia, leading to fatigue, weakness, and shortness of breath.   

Low platelets can increase the risk of bleeding, such as nosebleeds, easy bruising, and bleeding gums.   

Serious Infections: Due to the risk of low white blood cell counts, you are at increased risk of serious infections, including life-threatening infections.   

Pregnancy and Breastfeeding: 

Women: Lonsurf can harm an unborn baby. You must use effective birth control during treatment and for at least 6 months after your last dose.   

Men: Use condoms during sex with female partners who can become pregnant while you are taking Lonsurf and for 3 months after your last dose.   

Liver Problems: Lonsurf can cause liver problems. You will need regular blood tests to monitor your liver function.   

Kidney Problems: Lonsurf can affect kidney function. You will need regular blood tests to monitor your kidney function.   

Heart Problems: Lonsurf may increase the risk of heart problems, such as heart failure.

Hand-Foot Syndrome: This condition can cause pain, redness, swelling, and peeling of the skin on the palms of your hands and soles of your feet.

Possible Side Effects of Lonsurf 15mg Tablet?

Lonsurf (trifluridine and tipiracil) can cause a variety of side effects, some of which can be serious. Here are some of the possible side effects:   

Common Side Effects:

Low Blood Counts: 

Neutropenia (low white blood cell count): This is a common side effect of Lonsurf. It increases your risk of serious infections.   

Anemia (low red blood cell count): Can cause fatigue, weakness, and shortness of breath.   

Thrombocytopenia (low platelet count): Can increase the risk of bleeding.   

Fatigue: Feeling tired or weak.

Nausea: Feeling sick to your stomach.   

Diarrhea

Vomiting

Decreased appetite   

Mouth sores

Hair loss

Serious Side Effects:

Serious Infections: Due to the risk of low white blood cell counts.   

Liver Problems: Liver damage.   

Kidney Problems: Kidney impairment.   

Heart Problems: Heart failure.

Hand-Foot Syndrome: Pain, redness, swelling, and peeling of the skin on the palms of your hands and soles of your feet.   

Allergic Reactions: In rare cases, severe allergic reactions can occur.   

Other Possible Side Effects:

Changes in taste

Skin rash

Headache

Constipation

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