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How Does Keytruda 100mg Injection Work?
Keytruda (pembrolizumab) operates through a mechanism known as immune checkpoint inhibition. Here’s how it works:
Targeting PD-1: Keytruda is a monoclonal antibody that specifically binds to the programmed cell death protein 1 (PD-1) receptor found on T cells, a type of immune cell.
Blocking Interaction: By binding to PD-1, Keytruda prevents this receptor from interacting with its ligands, PD-L1 and PD-L2, which are often expressed on cancer cells. This interaction typically inhibits T cell activity, allowing cancer cells to evade the immune response.
Enhancing Immune Response: With the PD-1 pathway blocked, T cells are “unleashed,” enabling them to recognize and attack cancer cells more effectively. This enhances the body’s natural immune response against tumors.
How Should You Take Keytruda 100mg Injection?
Keytruda (pembrolizumab) should be taken as follows:
Administration Method: Keytruda is administered as an intravenous (IV) infusion. It must not be given as an IV push or bolus injection.
Infusion Duration: The infusion typically lasts for 30 minutes.
Dosage Schedule: The recommended dose is generally 2 mg/kg every 3 weeks, or a fixed dose of 200 mg for certain cancers, depending on the specific indication. Patients may continue treatment until disease progression or unacceptable toxicity occurs.
Before administration, Keytruda must be diluted in either 0.9% Sodium Chloride Injection or 5% Dextrose Injection.
The diluted solution should have a final concentration between 1 mg/mL and 10 mg/mL.
Visually inspect the solution for clarity and color; discard if any particulate matter is observed.
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