Gazyva Infusion 1000 mg/40 mL 1 Vial

How to use Gazyva Infusion 1000 mg/40 mL 1 Vial

Dilute and administer as IV infusion. Do not administer as an IV push or bolus. Do not mix obinutuzumab with other drugs.
Reconstitution: Dilute into a 0.9% sodium chloride PVC or non-PVC polyolefin infusion bag. Do not use other diluents such as dextrose (5%). Preparation of solution for infusion on day 1 (100 mg) and day 2 (900 mg) of cycle 1, withdraw 40 mL of drug solution from the vial. Dilute 4 mL (100 mg) of drug into a 100 mL 0.9% NaCl infusion bag for immediate administration. Dilute the remaining 36 mL (900 mg) into a 250 mL 0.9% NaCl infusion bag at the same time for use on day 2. Preparation of solution for infusion on day 8 and 15 of cycle 1 and day 1 cycles 26, withdraw 40 mL of drug solution from the vial. Dilute 40 mL (1000 mg) into a 250 mL 0.9% NaCl infusion bag. Mix diluted solution by gentle inversion. Do not shake or freeze. Stability: Store at 2°C to 8°C (36°F to 46°F) for up to 24 hours. After allowing the diluted bag to come to room temperature, use immediately. Clearly label each infusion bag.

What are the adverse effects of Gazyva Infusion 1000 mg/40 mL 1 Vial?

The most common adverse reactions (incidence =10%) were: infusion reactions, neutropenia, thrombocytopenia, anemia, pyrexia, cough, and musculoskeletal disorder.

What happens if I miss a dose of Gazyva Infusion 1000 mg/40 mL 1 Vial?

Recommended dose for 6 cycles (28 day cycles). 100 mg on day 1 cycle 1, 900 mg on day 2 cycle 1, 1000 mg on day 8 and 5 of cycle 1, 1000 mg on day 1 of cycles 2-6.

One of the following licensed pharmacy from the nearest location will deliver Gazyva Infusion 1000 mg/40 mL 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.