Caverject 20mcg Injection Solution (Aprostadil)

Caverject 20mcg injection contains Aprostadil which is now available in Pakistan at Jasmeds. The price range of the Caverject 20mcg injection is Rs 10,000/- to Rs 30,000/-.

Product Description

Brand: Caverject
Form: Injection
Packet Size: 1 Vial Injection
Active ingredient: Aprostadil
Manufacturer: Pfizer
Treatment: Erectile dysfunction

₨ 22,000

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Description

How Does Caverject 20mcg Injection Work?

Caverject 20 mcg Injection works primarily through the active ingredient alprostadil, a synthetic form of prostaglandin E1. Here’s how it functions:

Vasodilation: Alprostadil induces relaxation of the trabecular smooth muscle in the penis and dilates the cavernosal arteries. This process increases blood flow into the corpus cavernosum, leading to an erection.

Corporal Veno-Occlusive Mechanism: As blood fills the lacunar spaces within the corpus cavernosum, it compresses the venules against the tunica albuginea. This compression reduces venous outflow, helping to maintain penile rigidity during an erection.

Increased cAMP Levels: Alprostadil binds to specific receptors, which increases intracellular cyclic adenosine monophosphate (cAMP) levels. This biochemical pathway further enhances relaxation of smooth muscle and dilation of blood vessels.

How Should You Take Caverject 20mcg Injection?

To take Caverject 20 mcg Injection correctly, follow these guidelines:

Consult Your Doctor: Ensure you have been trained by a healthcare provider on how to use Caverject before self-injection.

Gather Supplies: You will need the Caverject vial, a syringe (1 mL to 3 mL), a 29 or 30 gauge needle for injection, and an alcohol swab.

Positioning: Sit or recline slightly when preparing for the injection. Retract the foreskin if uncircumcised.

Injection Site: Choose either the right or left lateral side of the penis (corpus cavernosum) for injection. Avoid visible veins and alternate sides with each injection.

Additional Details

Uses of the Caverject 20mcg Injection

Caverject 20 mcg Injection, containing the active ingredient alprostadil, is primarily used for the treatment of erectile dysfunction (ED) in adult males. Here are its main uses:

Erectile Dysfunction Treatment: Caverject is effective in treating ED by enhancing blood flow to the penis, allowing for the achievement and maintenance of an erection. It typically works within 5 to 20 minutes and can provide an erection lasting about 30 to 60 minutes.

Diagnostic Testing: Caverject is also utilized as an adjunct in the diagnosis of erectile dysfunction. It can help assess the erectile response during diagnostic tests, such as duplex or Doppler ultrasound imaging, by inducing a rigid erection.

Recommended Dosage of Caverject 20mcg Injection?

The recommended dosage of Caverject 20 mcg Injection varies based on the type of erectile dysfunction and individual response. Here are the guidelines:

For Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology:

Initial Dose: Start with 2.5 mcg injected intracavernosally.

Titration: If there is a partial response, a second dose of 2.5 mcg may be administered within 1 hour.

Further Titration: If needed, increase the dose in increments of 5 to 10 mcg at least 24 hours apart until optimal efficacy is achieved.

Maximum Dose: Do not exceed a total of 60 mcg in a single injection.

For Erectile Dysfunction of Pure Neurogenic Etiology (e.g., Spinal Cord Injury):

Initial Dose: Start with 1.25 mcg injected intracavernosally.

Titration: If there is a partial response, administer another 1.25 mcg within 1 hour.

Further Titration: Increase by doses of 5 mcg at least 24 hours apart as needed.

Maximum Dose: Again, do not exceed a total of 60 mcg.

Warnings and Precautions of Caverject 20mcg Injection

Caverject 20 mcg Injection has several important warnings and precautions that users should be aware of:

Prolonged Erection and Priapism: There is a risk of prolonged erections (lasting more than 4 hours) and priapism. To minimize this risk, titrate to the lowest effective dose and seek immediate medical attention if an erection persists longer than 4 hours.

Penile Fibrosis: Users may develop penile fibrosis or angulation. Regular physical examinations of the penis are recommended to monitor for signs of fibrosis, and treatment should be discontinued if such conditions develop.

Hypotension: Intracavernosal injections can increase blood levels of alprostadil, potentially leading to hypotension. Caution is advised in patients with known cavernosal venous leakage.

Injection Site Bleeding: Patients on anticoagulants (e.g., warfarin, heparin) may experience increased bleeding at the injection site. It is advised to compress the injection site for 5 minutes post-injection to minimize bleeding.

Cardiovascular Risks: Patients with underlying cardiovascular conditions should be evaluated before using Caverject, as sexual activity may pose additional risks.