Pulmonary fibrosis is a serious lung condition where scar tissue forms in the lungs, making it harder to breathe over time. One of the most common types is Idiopathic Pulmonary Fibrosis, which has no known cause and no cure.
Cases of IPF are steadily increasing in Pakistan and globally. One of the most widely recommended treatments available today is Ofev, also known by its generic name, nintedanib.
A common question is, “How long does Ofev take to start working?” While individual responses may differ, research suggests that some improvements can appear within a few weeks, with more noticeable results typically seen over 3 to 6 months.
This blog will explain what Ofev is, how it works, its benefits and risks, and whether it’s the right treatment for people with pulmonary fibrosis.
What is Ofev?
Ofev (brand name for nintedanib) is an oral prescription drug classified as a tyrosine kinase inhibitor. This means it works by blocking certain enzymes that cause lung tissue to scar and stiffen. It is one of the few antifibrotic medications approved for slowing the progression of pulmonary fibrosis. How does Ofev work? It interferes with the process of fibrosis, which is the thickening and scarring of connective tissue, especially in the lungs.
Ofev helps reduce the formation of scar tissue by targeting multiple pathways that are involved in fibrosis. It works on growth factors like VEGF, FGF, and PDGF, these are proteins that can promote the growth of fibrotic tissue in the lungs. By blocking these signals, Ofev can slow down how quickly the disease worsens, helping patients maintain better lung function for a longer time.
It is available in capsule form, typically taken as Ofev 150 mg twice daily, and can be purchased through authorized platforms like Jasmeds for added convenience and reliable delivery support.
What is Ofev Used For?
1. Idiopathic Pulmonary Fibrosis
Ofev is most widely known for treating Idiopathic Pulmonary Fibrosis. In this condition, lung tissue becomes thick and stiff without any known reason. IPF gradually gets worse, causing difficulty in breathing and reducing the ability to do daily activities.
Ofev is approved by the U.S. FDA and other global health authorities to help slow this progression. Clinical studies like INPULSIS-1 and INPULSIS-2 have shown that patients using Ofev experienced a slower rate of lung decline compared to those on placebo.
2. Chronic Fibrosing Interstitial Lung Disease
Apart from IPF, Ofev is also approved for treating other types of chronic fibrosing interstitial lung disease) with a progressive phenotype. These diseases behave like IPF, meaning they worsen over time.
Ofev helps slow the process of fibrosis, giving patients more time with better lung function.
3. Systemic Sclerosis-Associated Interstitial Lung Disease
Ofev is also used in treating Systemic Sclerosis-Associated Interstitial Lung Disease. This type of ILD is caused by an autoimmune condition called scleroderma. In SSc-ILD, Ofev has shown positive results in slowing down the loss of lung function, helping patients live more comfortably.
The FDA approved this use in 2019 after strong clinical results, making Ofev one of the few drugs that work for multiple lung-scarring diseases.
Role of Ofev for Pulmonary Fibrosis
Ofev plays a major role in slowing the progression of pulmonary fibrosis. But how does Ofev work specifically? It targets and blocks certain proteins that help form scar tissue.
Over time, this helps the lungs stay flexible and functional for longer periods. One important measure to check this is Forced Vital Capacity. FVC is the total amount of air a person can exhale after taking a deep breath.
Let’s look at the clinical trial evidence that supports Ofev effectiveness:
- INPULSIS-1: People on Ofev lost 115 mL/year of FVC vs. 240 mL in the placebo group. That’s a 125 mL/year difference.
- INPULSIS-2: Similar results showed a reduction of 114 mL/year vs. 207 mL in placebo—a 94 mL/year benefit.
- TOMORROW study: Ofev users lost only 60 mL/year compared to 191 mL/year in placebo, a 68% improvement.
In addition, Ofev helps prevent acute exacerbations and sudden worsening of the disease. In INPULSIS-2, patients on Ofev were 80% less likely to experience such episodes compared to those on placebo. While it is not a cure, Ofev is a proven method to slow down IPF progression and preserve lung health.
Side Effects of Ofev
Like all medications, Ofev medication comes with side effects. While not everyone gets them, it’s important to understand what might happen and when to talk to a doctor.
1. Digestive System Issues
The most common side effect is diarrhea. Studies show that more than half of Ofev users experience this at some point. Nausea, vomiting, and stomach-area pain are also possible. These issues can usually be managed with diet changes or other medications, but in severe cases, dosage adjustments may be needed.
2. Liver Effects
Ofev may affect liver function by increasing liver enzyme levels. This can be serious if not monitored. Patients usually get regular blood tests to check their liver enzymes during treatment. If levels go too high, the doctor may lower the dose or stop the medicine.
3. Appetite and Weight
Loss of appetite and weight loss are common among patients. This can be concerning, especially for those who are already weak. Patients should maintain a high-protein, balanced diet and consult with a nutritionist if needed.
4. Cardiovascular Effects
Ofev can cause high blood pressure in some individuals. Monitoring blood pressure regularly during treatment is important. If levels become too high, medications may be prescribed to manage it.
5. Neurological Symptoms
Some people report having headaches while taking Ofev. These are usually mild and temporary, but if persistent, it’s worth mentioning to a healthcare provider.
6. General Tolerability Concerns
The overall tolerability of Ofev depends on individual health conditions. Some people may need to pause treatment or change the dosage. It’s important to have a regular follow-up plan with the doctor to manage any complications.
Final Thoughts
Ofev’s effectiveness in treating pulmonary fibrosis is backed by strong scientific research. It helps slow the progression of diseases like IPF, chronic fibrosing ILD, and SSc-ILD, giving patients better quality of life and more time with preserved lung function. While it is not a cure, Ofev offers a practical and tested solution for managing difficult lung diseases.
If you’re considering Ofev, make sure to consult your doctor about the benefits and risks. Also, make sure to stay consistent with follow-ups and testing.
If you’re in Pakistan, securing the best price for Ofev 150 mg is easy and reliable. You can conveniently buy Ofev online through trusted pharmacies like Jasmeds, ensuring both affordability and safe, hassle-free delivery right to your doorstep.
